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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April, May and September are the most popular months to cruise between Spain and Italy and there are 205 departures available from sixteen of the world's leading cruise lines.
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109 Cruises (205 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ships: Sun Princess, Sun Princess
Departures: Jun 2024 to Aug 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,675
OCEANVIEW
$1,873
BALCONY
$1,982
SUITE
$2,667
From 1,675
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Aug 2024 to Aug 2026
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$14,845
Save 1,151
From 9,895
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,807
OCEANVIEW
$10,569
BALCONY
$15,608
SUITE
$21,152
Save 2,073
From 9,807
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 April 2025
Countries Visited: Spain, France, Italy, Montenegro (+2 more), Croatia, Slovenia
INSIDE
$5,078
OCEANVIEW
$5,539
BALCONY
$6,229
SUITE
$7,953
From 5,078
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,090
OCEANVIEW
$6,552
BALCONY
$7,241
SUITE
$9,540
From 6,090
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$3,216
OCEANVIEW
$3,678
BALCONY
$4,368
SUITE
$6,091
From 3,216
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Greece (+2 more), Croatia, Montenegro
Have It All Offer
INSIDE
$3,941
OCEANVIEW
$4,139
BALCONY
$5,278
SUITE
$7,159
From 3,941
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,301
SUITE
$13,907
Save 159
From 8,301
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
INSIDE
$1,375
OCEANVIEW
-
BALCONY
$1,560
SUITE
$2,068
From 1,375
View Trip
11 Day French, Spanish & Italian Rivieras with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$3,474
OCEANVIEW
$2,919
BALCONY
$3,907
SUITE
$3,983
From 2,919
View Trip
8 Day Mediterranean Spring with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 06 May 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$4,129
OCEANVIEW
$4,357
BALCONY
$6,109
SUITE
$8,238
Save 2,031
From 4,129
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 August 2024
Countries Visited: Spain, Italy, France
Exclusive Offer
INSIDE
$1,988
OCEANVIEW
$2,508
BALCONY
$2,858
SUITE
$7,161
Save 2,764
From 1,988
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
$490
OCEANVIEW
$569
BALCONY
$688
SUITE
$1,262
From 490
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$4,112
SUITE
$8,518
From 3,172
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 29 April 2025
Countries Visited: Spain, Tunisia, Sicily, Italy
Exclusive Deal
INSIDE
$717
OCEANVIEW
$855
BALCONY
$1,004
SUITE
$1,330
From 717
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$610
BALCONY
$738
SUITE
$1,441
From 610
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 October 2024
Countries Visited: Spain, Italy
Best Deal Offer
INSIDE
$362
OCEANVIEW
$490
BALCONY
$540
SUITE
-
From 362
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 03 October 2024
Countries Visited: Spain, France, Italy
Exclusive Offer
INSIDE
$2,925
OCEANVIEW
$2,767
BALCONY
$3,045
SUITE
$7,129
Save 3,265
From 2,767
View Trip
11 Day Flavors Of The Mediterranean with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 18 September 2024
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$10,802
BALCONY
$13,603
SUITE
$16,563
Save 5,248
From 10,802
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 23 June 2024
Countries Visited: Spain, France, Italy, Sicily (+2 more), Greece, Croatia
INSIDE
$2,139
OCEANVIEW
$2,599
BALCONY
$2,674
SUITE
$3,699
From 2,139
View Trip
29 Day Mediterranean And Greek Islands with Cunard
Cruise

29 Days (28 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 May 2026
Countries Visited: Spain, Greece, Turkey, France (+3 more), Italy, Corsica, Sicily
INSIDE
$5,602
OCEANVIEW
$6,147
BALCONY
$7,137
SUITE
$14,859
From 5,602
View Trip
8 Day Spain, France & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 06 July 2024
Countries Visited: Spain, France, Italy
Exclusive Offer
INSIDE
$2,243
OCEANVIEW
$2,575
BALCONY
$3,185
SUITE
$7,207
Save 2,642
From 2,243
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia (+2 more), Montenegro, Greece
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,657
SUITE
$7,667
From 2,766
View Trip
22 Day Barcelona to Venice with Silversea
Cruise

22 Days (21 Nights) Barcelona to Venice
Cruise Line: Silversea
Ship: Silver Moon
Departure: 16 August 2024
Countries Visited: Spain, France, Italy, Sardinia (+4 more), Sicily, Malta, Montenegro, Croatia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,780
BALCONY
$23,562
SUITE
-
From 21,780
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$1,962
SUITE
$4,189
From 1,516
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 12 July 2024
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,394
SUITE
-
From 11,394
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sky, Viking Star, Viking Venus, Viking Vesta
Departures: Jul 2024 to Jul 2026
Countries Visited: Spain, France, Monaco, Italy (+2 more), Sicily, Croatia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,697
SUITE
$14,350
Save 1,983
From 9,697
View Trip
8 Day Florence, Rome, Palma & More with Virgin Voyages
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 29 June 2025
Countries Visited: Spain, France, Corsica, Italy
Up to 80% Off Second Sailor + Free Upgrade
INSIDE
$2,288
OCEANVIEW
$2,679
BALCONY
$2,951
SUITE
$6,552
From 2,288
View Trip
8 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,816
SUITE
$8,286
From 6,816
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise

12 Days (11 Nights) Santa Cruz de Tenerife to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+2 more), Italy, Croatia
Save And Sail Offer
INSIDE
$1,567
OCEANVIEW
$1,914
BALCONY
$2,844
SUITE
$4,280
From 1,567
View Trip
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