Home > All River Cruises > Asia River Cruises > Mekong River Cruises > Cambodia > September 2025

Cambodia River Cruises Starting In September 2025

If you're looking at joining a river cruise through Cambodia in September 2025, we have 47 unique river cruise itineraries and 756 departures available, operated by eight of the world's leading river cruise lines departing in September.
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Departures (September 2025)
< August 2025 October 2025 >
Duration
8 Days
25 Days
Countries Visited
Start & End Cities
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Price
$2,700pp
$34,080pp
Countries
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47 River Cruises (756 River Cruise Departures)
12 Day Essential Vietnam and Cambodia with Travelmarvel
River Cruise
 (6)

12 Days Siem Reap to Ho Chi Minh City
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Cambodia, Vietnam
Exclusive Deal
Save 2,235
From 3,665
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12 Day Essential Vietnam and Cambodia with Travelmarvel
River Cruise
 (14)

12 Days Ho Chi Minh City to Siem Reap
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,236
From 3,665
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13 Day Vietnam and Cambodia Highlights with APT
River Cruise
 (2)

13 Days Siem Reap to Ho Chi Minh City
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Apr 2026
Rivers: Mekong
Countries Visited: Cambodia, Vietnam
Exclusive Deal
Save 2,075
From 7,329
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17 Day Discover Vietnam and Cambodia with Travelmarvel
River Cruise
 (5)

17 Days Hanoi to Ho Chi Minh City
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,059
From 6,043
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8 Day Majestic Mekong Cruise with Travelmarvel
River Cruise
 (7)

8 Days Ho Chi Minh City to Siem Reap
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 732
From 2,773
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13 Day Vietnam and Cambodia Highlights with APT
River Cruise
 (7)

13 Days Ho Chi Minh City to Siem Reap
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Apr 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,075
From 7,329
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11 Day Spiritual Cambodia and The Mekong with APT
River Cruise

11 Days Siem Reap to Ho Chi Minh City
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Apr 2026
Rivers: Mekong
Countries Visited: Cambodia, Vietnam
Exclusive Deal
Save 1,561
From 6,140
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8 Day Mekong Discovery with Avalon River Cruises
River Cruise
 (2)

8 Days Phnom Penh to Ho Chi Minh City
Operated By: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2024 to Dec 2025
Rivers: Mekong
Countries Visited: Cambodia, Vietnam
Exclusive DealEarlybird Offer
Save 3,059
From 4,068
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20 Day Wonders of Vietnam and Cambodia with Travelmarvel
River Cruise
 (8)

20 Days Hanoi to Siem Reap
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,663
From 6,935
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21 Day Best of Vietnam and Cambodia with APT
River Cruise
 (5)

21 Days Hanoi to Siem Reap
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Apr 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,612
From 11,291
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21 Day Best of Vietnam and Cambodia with APT
River Cruise
 (3)

21 Days Ho Chi Minh City to Ho Chi Minh City
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Apr 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive DealFlights Included
Save 2,618
From 11,687
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17 Day Vietnam and Cambodia Discovery with APT
River Cruise
 (3)

17 Days Hanoi to Siem Reap
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Apr 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,594
From 9,607
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25 Day Vietnam and Cambodia Grand Tour with APT
River Cruise
 (3)

25 Days Hanoi to Siem Reap
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,636
From 13,569
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16 Day Discover Vietnam and Cambodia with Travelmarvel
River Cruise
 (2)

16 Days Hanoi to Siem Reap
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,058
From 5,646
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8 Day Mekong Discovery with Avalon River Cruises
River Cruise
 (2)

8 Days Ho Chi Minh City to Phnom Penh
Operated By: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2024 to Nov 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive DealEarlybird Offer
Save 3,059
From 4,494
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15 Day Timeless Wonders of Vietnam, Cambodia & the Mekong with Uniworld River Cruises
River Cruise
 (2)

15 Days Hanoi to Ho Chi Minh City
Ships: Mekong Jewel
Departures: Sep 2024 to Dec 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Earlybird SavingLast Minute Deal
Save 1,613
From 10,783
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17 Day Vietnam and Cambodia Discovery with APT
River Cruise
 (2)

17 Days Hanoi to Ho Chi Minh City
Operated By: APT
Ships: Mekong Serenity
Departures: Jul 2024 to Apr 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,597
From 9,904
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16 Day Fascinating Vietnam, Cambodia & the Mekong River with Hanoi & Ha Long Bay with Avalon River Cruises
River Cruise
 (1)

16 Days Hanoi to Siem Reap
Operated By: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2024 to Nov 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive DealEarlybird Offer
Save 3,099
From 8,694
View Trip
8 Day Majestic Mekong Cruising with Travelmarvel
River Cruise
 (1)

8 Days Siem Reap to Ho Chi Minh City
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Cambodia, Vietnam
Exclusive Deal
Save 732
From 2,773
View Trip
23 Day Natural Wonders of Vietnam and Cambodia with Travelmarvel
River Cruise
 (1)

23 Days Hanoi to Siem Reap
Operated By: Travelmarvel
Ships: RV Apsara
Departures: Jul 2024 to Mar 2026
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
Save 2,867
From 7,629
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23 Day Grand Tour of Vietnam & Cambodia with Emerald Cruises
River Cruise
 (4)

23 Days Hanoi to Siem Reap
Operated By: Emerald Cruises
Ship: Emerald Harmony
Departures: Jul 2024 to Sep 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
INSIDE
-
RIVER VIEW
$7,618
BALCONY
$8,405
SUITE
$10,286
Save 2,087
From 7,618
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23 Day Grand Tour of Vietnam & Cambodia with Emerald Cruises
River Cruise
 (4)

23 Days Hanoi to Ho Chi Minh City
Operated By: Emerald Cruises
Ship: Emerald Harmony
Departures: Aug 2024 to Sep 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
INSIDE
-
RIVER VIEW
$8,212
BALCONY
$8,999
SUITE
$10,880
Save 2,087
From 8,212
View Trip
10 Day Majestic Mekong Cruise with Emerald Cruises
River Cruise
 (4)

10 Days Ho Chi Minh City to Phnom Penh
Operated By: Emerald Cruises
Ship: Emerald Harmony
Departures: Aug 2024 to Sep 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
INSIDE
-
RIVER VIEW
$4,495
BALCONY
$5,282
SUITE
$7,163
Save 555
From 4,495
View Trip
10 Day Majestic Mekong Cruise with Emerald Cruises
River Cruise
 (4)

10 Days Phnom Penh to Ho Chi Minh City
Operated By: Emerald Cruises
Ship: Emerald Harmony
Departures: Aug 2024 to Oct 2025
Rivers: Mekong
Countries Visited: Cambodia, Vietnam
Exclusive Deal
INSIDE
-
RIVER VIEW
$4,495
BALCONY
$5,282
SUITE
$7,163
Save 555
From 4,495
View Trip
19 Day Treasures & Temples of Vietnam & Cambodia with Emerald Cruises
River Cruise
 (4)

19 Days Hanoi to Ho Chi Minh City
Operated By: Emerald Cruises
Ships: Emerald Harmony
Departures: Jul 2024 to Sep 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
INSIDE
-
RIVER VIEW
$6,777
BALCONY
$7,564
SUITE
$9,445
Save 2,078
From 6,777
View Trip
15 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (4)

15 Days Siem Reap to Ho Chi Minh City
Operated By: Emerald Cruises
Ships: Emerald Harmony
Departures: Jul 2024 to Sep 2025
Rivers: Mekong
Countries Visited: Cambodia, Vietnam
Exclusive Deal
INSIDE
-
RIVER VIEW
$4,945
BALCONY
$5,732
SUITE
$7,613
Save 2,060
From 4,945
View Trip
15 Day Wonders of Vietnam, Cambodia & the Mekong with Emerald Cruises
River Cruise
 (4)

15 Days Ho Chi Minh City to Siem Reap
Operated By: Emerald Cruises
Ships: Emerald Harmony
Departures: Aug 2024 to Sep 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
INSIDE
-
RIVER VIEW
$4,945
BALCONY
$5,732
SUITE
$7,613
Save 2,060
From 4,945
View Trip
15 Day Treasures of the Mekong Meandering Cruise with Scenic
River Cruise

15 Days Ho Chi Minh City to Siem Reap
Operated By: Scenic
Ship: Scenic Spirit
Departures: Jul 2024 to Dec 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
INSIDE
-
RIVER VIEW
-
BALCONY
$7,123
SUITE
$9,791
Save 4,389
From 7,123
View Trip
15 Day Timeless Wonders of Vietnam, Cambodia & the Mekong with Uniworld River Cruises
River Cruise

15 Days Ho Chi Minh City to Hanoi
Ships: Mekong Jewel
Departures: Sep 2024 to Nov 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Earlybird SavingLast Minute Deal
Save 1,596
From 10,783
View Trip
20 Day Highlights of Cambodia, Vietnam & Luxury Mekong with Scenic
River Cruise

20 Days Hanoi to Ho Chi Minh City
Operated By: Scenic
Ship: Scenic Spirit
Departures: Jul 2025 to Sep 2025
Rivers: Mekong
Countries Visited: Vietnam, Cambodia
Exclusive Deal
INSIDE
-
RIVER VIEW
-
BALCONY
$11,331
SUITE
$13,999
Save 4,428
From 11,331
View Trip
Results: 1-30 of 47

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Trip Lengths

3 Week

Departure Months

July 2024 August 2024 September 2024 October 2024 November 2024 December 2024 January 2025 February 2025 March 2025 April 2025 May 2025 July 2025 August 2025 September 2025 October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026 August 2026 September 2026 October 2026 November 2026 December 2026

Cities

Siem Reap

Routes

Hanoi to Siem Reap Ho Chi Minh City to Siem Reap Siem Reap to Ho Chi Minh City

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